Sara Light

Sara Light, image

I'm a Bioinformatician at Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University affiliated with Bioinformatics for Life Sciences (BILS).

Address

Science for Life Laboratory Stockholm
Box 1031
SE-17121 Solna
Sweden

Email: sara.light AT scilifelab.se


Current research

I have a broad background in bioinformatics, including analysis of metabolic and protein-protein intereaction networks, prokaryotic genome annotation, metagenomics, phylogenetics and protein domain analysis.

In the last year I have worked on four major projects:

- The evolution of the actin-crosslinker Filamin, a domain repeat containing protein that has undergone repeat expansions in several invertebrates.

- I have worked as a support bioinformatician on a project that serves to annotate the genome of a prokaryotic pathogen (together with Jan-Willem de Gier's group at DBB).

- Exploration of attenuated translation of membrane proteins together with Dan Daley's group.

- The evolution of long repeat proteins.

Research interests

  • Comparative genomics
  • Protein-protein interactions
  • Genome evolution
  • Cancer genomics
  • Metagenomics
  • Protein domain analysis
  

Publications

1. Network analysis of metabolic enzyme evolution in Escherichia coli.
Sara Light and Per Kraulis
BMC Bioinformatics 2004 Feb 18;5:15.

2. Preferential attachment in the evolution of metabolic networks.
Sara Light, Per Kraulis and Arne Elofsson
BMC Genomics 2005 Nov 10;6(1):159. 

3. Domain rearrangements in protein evolution.
Åsa K. Björklund, Diana Ekman, Sara Light, Johannes Frey-Skött and Arne Elofsson
JMB 2005 Nov 4;353(4):911-923. 

4. What properties characterize the hub proteins of the protein-protein interaction network of S.cerevisiae ?
Diana Ekman*, Sara Light*, Åsa K. Björklund and Arne Elofsson
* These authors contributed equally
Genome Biology 2006, 7:R45. 

5. Evolution after gene duplication: Models, mechanisms, sequences, systems and organisms
Christian Roth, Shruti Rastogi, Lars Arvestad, Katharina Dittmar, Sara Light, Diana Ekman and David A. Liberles
J Exp Zool B Mol Dev Evol., 2007, 308(1):58-73.

6. Investigations into the evolution of biological networks
Sara Light
PhD thesis 2006, ISBN 91-7155-273-1.

7. Quantitative assessment of the structural bias in protein-protein interaction assays
Åsa Björklund, Sara Light, Linea Hedin and Arne Elofsson
Proteomics, 2008, 8: 4657-67.

8. Nebulin - a study of protein repeat evolution
Åsa Björklund, Sara Light*, Rauan Sagit* and Arne Elofsson
* These authors contributed equally
JMB, 402:38-51, 2010.

9. Manipulating the genetic code for  membrane protein production: What have we learnt so far?
Morten M.H. Norholm, Sara Light, Minttu T.I. Virkki, Arne Elofsson, Gunnar von Heijne and Daniel O. Daley
BBA Biomembranes, accepted, 2011.

10. The evolution of Filamin and its interaction partners - a protein domain perspective
Sara Light, Rauan Sagit, Sujay S. Ithychanda, Jun Qin and Arne Elofsson
Submitted, 2011.