TAED entry 5 from Master Catalog version 2.1x family 21674 is parathyroid hormone receptor.
Ka/Ks > 0.6 has been measured following species specific evolution within Tetrapoda.
The information from EGAD is appended below:
This TAED entry has sequence similarity to EGAD entry:
HT27823 corticotropin-releasing factor receptor 2 , with a known function in: cell signaling/cell communication.
HT27823 corticotropin-releasing factor receptor 2 , with a known function in: receptors/cell signaling.
The information from PMD is appended below:
This TAED entry has sequence similarity to PMD entry: A940231
Protein=Calcitonin receptor
Source=Human
genotype 1-Val 171 MetPhe 173 LeuLeu 192 IleGly 193 SerLys--Leu 175-190 (deletion)(replaced by pig loop 1 site)
genotype 2-Ala 267 SerThr 270 AlaLeu 272 GlyArg 276 TrpTyr 279 HisLeu 280 Val(replaced by pig loop 2 site)
genotype 3-Thr 341 LysMet 343 LeuArg 344 LysThr 346 SerHis 347 Glu(replaced by pig loop 3 site)
genotype 4-Ile--Ala 406-490 of human replaced by corresponding region of pig. (C-terminal site)
genotype 5-Replaced by pig loop 2 & C-terminal sites.
genotype 6-Replaced by pig loop 3 & C-terminal sites.
genotype 7-Replaced by pig loop 1 & C-terminal sites.
genotype 8-Replaced by pig loop 1, 2 & C-terminal sites.
genotype 9-Replaced by pig loop 1, 3 & C-terminal sites.
genotype 10-Replaced by pig loop 1, 2 & 3 sites.
genotype 11-Replaced by pig loop 1, 2, 3 & 4 sites.
phenotype1-Stimulation of cAMP and inositol phosphate [+] (not as effective as pig)
phenotype2-Stimulation of cAMP [+] and no stimulation of inositol phosphate like as wild-type human protein.
phenotype3-Stimulation of cAMP [=] and no stimulation of inositol phosphate like as wild-type human protein.
phenotype4-Stimulation of cAMP [+] and no stimulation of inositol phosphate like as wild-type human protein.
phenotype5-Stimulation of cAMP [=] and inositol phosphate [+]
phenotype6-Stimulation of cAMP [+] and inositol phosphate [+]
phenotype7-Stimulation of cAMP [+] and inositol phosphate [+]
phenotype8-Stimulation of cAMP [+] and inositol phosphate [+]
phenotype9-Stimulation of cAMP [+] and inositol phosphate [+ +]