The only currently available documentation is the original publication. We appologize for this, and hope to be able to provide a more complete documentation online in future versions of this service.
If you use this service, please cite the following reference:
"Membrane Protein Structure Prediction, Hydrophobicity Analysis and the Positive-inside Rule", Gunnar von Heijne, J. Mol. Biol. (1992) 225, 487-494
A comparison with other methods can be found in:
"Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method", Miklos Cserzo, Erik Wallin, Istvan Simon, Gunnar von Heijne, and Arne Elofsson, to appear in Protein Engineering, vol. 10, no. 6, (1997)